Impact of Growing Location on Kakadu Plum Fruit Composition and In Vitro Bioactivity as Determinants of Its Nutraceutical Potential

Growing location is known to affect the metabolite content and functionality of wild harvested fruits. Terminalia ferdinandiana, commonly as Kakadu plum (KP), among most commercially important native Australian bush foods. Therefore, we evaluated composition in vitro bioactivity aqueous acidified ethanol (AAE) water extracts prepared from KP fruit Northern Territory (NT) Western Australia (WA). Compositional analysis included vitamin C, total ellagic acid (TEA), phenolic (TPC), while was assessed through anti-inflammatory (RAW 264.7 macrophages) activity cell viability (Hep G2) assay. The IC50 ranged 33.3 166.3 µg/mL for NO inhibition CC50 1676 7337 Hep G2 inhibition. AAE NT exhibited potent impacted more than other extracts, likely due TEA (3189 mg/100 g dry weight (DW)), C (180.5 mg/g DW) TPC (196 mg GAE/g being higher any extract. Overall, findings present study are promising using derived products functional foods, nutraceuticals, or dietary supplements.